Prof. Dr. Michio Iwaoka

Academic Career
Research Associate 1989-1996, Department of Chemistry, School of Arts and Sciences, The University of Tokyo
Research Associate 1996-2003, Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo
Associate Professor 2003-2009, Department of Chemistry, School of Science, Tokai University
Professor 2009-, Department of Chemistry, School of Science, Tokai University
Diretor 2022-, Institute of Advanced Biosciences, Tokai University

Awards
Lecture Award 1994, Chemical Society of Japan, “NMR Observation of the Selenenic Acid Intermediate in a Glutathione Peroxidase Model System.”
Frontier of Chemistry 2000, Chemical Society of Japan, “Quantitative Evaluation and Applications of Interatomic Weak Interactions Involving Group 16 Elements.”
Science Award 2022, School of Science, Tokai University.
Selected in the World Ranking Top 2% Scientists, Oxford University, DOI: 10.17632/btchxktzyw.4

Other Activities
Visiting Scientist 1995-1997, Department of Chemistry, Cornell University, USA (Professor H. A. Scheraga)
Visiting Scientist 1998, Department of Chemistry, Cornell University, USA (Professor H. A. Scheraga)
Lecturer (part-time) 1999-2003, The University of Electro-Communications, Japan
Visiting Professor 2002, Korean Institute of Advanced Technology (KIAS), Korea (Professor J. Lee)
Lecturer (part-time) 2004, Yokohama City University, Japan
Lecturer (part-time) 2005-2009, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Visiting Professor 2008, Department of Chemistry, Cardiff University, UK (Professor T. Wirth)
Visiting Professor 2010, Korean Institute of Advanced Technology (KIAS), Korea (Professor J. Lee)
Lecturer (part-time) 2010, Kochi University, Japan

Editorial Board Member of Molecules (MDPI) 2020-
Co-Editor of Current Chemical Biology (Bentham) 2020-
Editorial Board Member of Main Group Chemistry (IOS) 2021-

Memberships
The Chemical Society of Japan; the American Chemical Society; the Society of Synthetic Organic Chemistry, Japan; the Biophysical Society of Japan; Protein Science Society of Japan, Japanese Peptide Society

Scopus h-index 32

Selected publications (times cited)

1. A Model Study on the Effect of an Amino Group on the Antioxidant Activity of Glutathione Peroxidase.M. Iwaoka, S. Tomoda, J. Am. Chem. Soc., 1994, 116, 2557-2561. (322)
2. Statistical and Theoretical Investigations on the Directionality of Nonbonded S•••O Interactions. Implications for Molecular Design and Protein Engineering. M. Iwaoka, S. Takemoto, S. Tomoda, J. Am. Chem. Soc., 2002, 124, 10613-10620. (263)
3. Nature of the Intramolecular Se•••N Nonbonded Interaction of 2-Selenobenzylamine Derivatives. An Experimental Evaluation by 1H, 77Se, and 15N NMR Spectroscopy.M. Iwaoka, S. Tomoda, J. Am. Chem. Soc., 1996, 118, 8077-8084. (241)
4. Nature of Nonbonded Se•••O Interactions Characterized by 17O NMR Spectroscopy and NBO and AIM Analyses. Michio Iwaoka, Hiroto Komatsu, Takayuki Katsuda, Shuji Tomoda, J. Am. Chem. Soc., 2004, 126, 5309-5317. (176)
5. Hydrogen-bonding Nature of the CH/π Interaction as Evidenced by Crystallographic Database Analyses and ab initio Molecular Orbital Calculations. O. Takahashi, Y. Kohno, S. Iwasaki, K. Saito, M. Iwaoka, S. Tomoda, Y. Umezawa, S. Tsuboyama, M. Nishio, Bull. Chem. Soc. Jpn., 2001, 74, 2421-2430. (150)
6. A Water-Soluble Cyclic Selenide with Enhanced Glutathione Peroxidase-Like Catalytic Activities. F. Kumakura, B. Mishra, K. I. Priyadarsini, M. Iwaoka, Eur. J. Org. Chem., 2010, 440-445. (121)
7. Design of Optically Active Selenium Reagents Having a Chiral Tertiary Amino Group and Their Application to Asymmetric Inter- and Intramolecular Oxyselenenylations. K. Fujita, K. Murata, M. Iwaoka, S. Tomoda, Tetrahedron, 1997, 53, 2029-2048. (109)
8. Hypervalent nonbonded interactions of a divalent sulfur atom. Implications in protein architecture and the functions. M. Iwaoka, N. Isozumi, Molecules, 2012, 17, 7266-7283. (103)
9. First Observation of a C‑H•••Se "Hydrogen Bond". M. Iwaoka, S. Tomoda, J. Am. Chem. Soc., 1994, 116, 4463-4464. (96)
10. Catalytic Conversion of Alkenes into Allylic Ethers and Esters Using Diselenides Having Internal Tertiary Amines. M. Iwaoka, S. Tomoda, J. Chem. Soc., Chem. Commun.,1992, 1165-1167. (64)
11. Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue. K. Arai, T. Takei, M. Okumura, S. Watanabe, Y. Amagai, Y. Asahina, L. Moroder, H. Hojo, K. Inaba, M. Iwaoka, Angew. Chem., Int. Ed., 2017, 56, 5522–5526. (60)
12. Regeneration of Three-Disulfide Mutants of Bovine Pancreatic Ribonuclease A Missing the 65-72 Disulfide Bond. Characterization of a Minor Folding Pathway of Ribonuclease A and Kinetic Roles of Cys65 and Cys72. M. Iwaoka, D. Juminaga, H. A. Scheraga, Biochemistry, 1998, 37, 4490-4501. (48)
13. Antioxidative Glutathione Peroxidase Activity of Selenoglutathione. S. Yoshida, F. Kumakura, I. Komatsu, K. Arai. Y. Onuma. H. Hojo. B. G. Singh, K. I. Priyadarsini, M. Iwaoka, Angew. Chem. Int. Ed., 2011, 50, 2125-2128. (47)
14. From Sulfur to Selenium. A New Research Arena in Chemical Biology and Biological Chemistry. M. Iwaoka, K. Arai, Curr. Chem. Biol., 2013, 7, 2–24. (46)
15. Stable Selones in Glutathione-Peroxidase-Like Catalytic Cycle of Selenonicotinamide Derivative. P. Ptabhu, B. G. Singh, M. Noguchi, P. P. Phadnis, V. K. Jain, M. Iwaoka, K. I. Priyadarsini, Org. Biomol. Chem., 2014, 12, 2404-2412. (45)
16. Rapid and Quantitative Disulfide Bond Formation for a Polypeptide Chain Using a Cyclic Selenoxide Reagent in an Aqueous Medium. K. Arai, K. Dedachi, M. Iwaoka, Chem. Eur. J., 2011, 17, 481–485. (38)
17. Selenoglutathione Diselenide: Unique Redox Reactions in the GPx-Like Catalytic Cycle and Repairing of Disulfide Bonds in Scrambled Protein. S. Shimodaira, Y. Asano, K. Arai, M. Iwaoka, Biochemistry, 2017, 56, 5644-5653. (33)
18. Solvent Effects on the φ-ψ Potential Surfaces of Glycine and Alanine Dipeptides Studied by PCM and I-PCM Methods. M. Iwaoka, M. Okada, S. Tomoda, S., J. Mol. Struct. (THEOCHEM), 2002, 586, 111-124. (33)