Organic chemistry approaches to biological phenomena
－ for elucidation of biological functions of selenium and the mechanism of protein folding
Activities
- We conducted joint research at a university in Brazil during summer vacation (29 September, 2023)
Takehiko Ikeda, a master-course student of Graduate School of Science, visited Brazil at The Center of Chemical, Food, and Pharmaceutical Sciences, The Federal University of Pelotas during this summer vacation and worked in the research on the biological activity assessments of organoselenium compounds that he synthesized in Japan. (For details, see the news of Department of Chemistry, Tokai University.) - A graduate student from Mumbai University joined our group to promote research projects (28 September, 2023)
Mr. Vishal, a graduate student of Mumbai University, came to our group from August 2023 to promote the international joint research project. He is now working on the synthesis of new-type nucleic acid derivatives having a 4-seleno-threose skeleton. “I am enjoying not only the research but also inter-personal interactions with the people in the laboratory”, he says. - Professor Michio Iwaoka selected as the World Ranking Top 2% Scientists (24 February, 2023)
Professor Michio Iwaoka, a director of Institute of Advanced Biosciences, is a worldwide leading scientist in the fields of Organic Chemistry and Protein Science, especially in the study of organic reactions, enzyme mimetics, and drug development. Recently, he ranked in top 2% scientists announced by Stanford University. See https://elsevier.digitalcommonsdata.com/datasets/btchxktzyw/4. - We moved to new laboratory at the Institute of Advanced Biosciences (24 February, 2023)
Professor Michio Iwaoka was appointed as a director of the institute of Advanced Biosciences, Tokai University, since April 2022. Accordingly, our laboratory has moved from Building 17 to the Institute of Advanced Biosciences in June, 2022. We are starting new projects in the new laboratory. - From past activities Since 2003
Activities
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学会発表、卒研発表、修士・博士論文公聴会、論文投稿などに関する情報を紹介
Read more教員紹介
岩岡 道夫 教授岩岡 道夫 教授Dr. Michio Iwaoka(Professor of Department of Chemistry, S...
Read moreProf. Dr. Michio Iwaoka
Prof. Dr. Michio IwaokaDr. Michio Iwaoka (Professor of Department of Chemistr...
Read more東海大学理学部化学科 岩岡研究室
生命現象への有機化学的アプローチ－ セレンの生理活性とタンパク質のフォールディング機構の解明を目指してお知らせ
Read moreTokai Univesity, Department of Chemistry, Iwaoka Laboratory
Organic chemistry approaches to biological phenomena－ for elucidation of biological funct...
Read moreグルタチオンペルオキシダーゼの酵素モデル
セレン原子を活性中心とする抗酸化酵素であるグルタチオンペルオキシダーゼ（GPx）は，細胞内の代謝によって生じる過酸化物を分解し，無害化しています。 この酵素のモデル化合物として，...
Read moreEnzyme Models of Glutathione Peroxidase (GPx)
Glutathione peroxidase is an antioxidant enzyme that contains a selenium atom at the acti...
Read more含セレンアミノ酸およびペプチドの合成
タンパク質中には、システイン、メチオニンといったイオウを含んだアミノ酸が含まれています。 システインやメチオニンに含まれるイオウ原子を、同族で重いセレン原子に置換することができた...
Read moreSynthesis of Selenoamino Acids & Peptides
Cysteine and methionine are the amino acids with a sulfur atom, which can be a useful pro...
Read moreフォールディング実験
タンパク質はどのようにして折り畳まれる（フォールディングする）のか。新規に開発したセレン試薬を用いてタンパク質のフォールディング実験を行うと、 フォールディング反応は短い時間で終...
Read moreExperiments of Protein Folding
How does a protein fold ? When a protein folding experiment was carried out by ...
Read moreSAAP力場の開発
タンパク質はどのように折り畳まれるのか――私たちが観察したくても、その過程を見ることはできません。 そこで威力を発揮するのが、コンピューターによる分子シミュレーションです。これに...
Read moreThe SAAP Force Field Project.
Even if we tried to observe protein folding processes by experiment, they cannot be seen ...
Read moreタンパク質立体構造の安定化因子の解析
近年、2価の硫黄原子と酸素原子や窒素原子といったヘテロ原子との間の非共有結合性相互作用（S···X相互作用）がタンパク質の立体構造を安定化し、その生物学的機能や分子進化とも関連し...
Read moreDatabase Analysis of Weak Interactions in Protein Architecture
Nonbonded interactions between a divalent sulfur atom and polar functional groups, i.e., ...
Read more実験の様子
実験は、先進生命科学研究所の3階で行っています。理論についても、先進生命科学研究所の3階で行っています。実験室の様子実験で使用する主な機器凍結乾燥機、分取...
Read moreView of our laboratory
Experimental Group: Institute of Advanced Biosciences 3rd floorTheoretical Group: Institu...
Read moreResearch
Glutathione Peroxidase - Selenocysteine - Protein Folding - Force Field DevelopmentAf...
Read more研究内容
グルタチオンペルオキシダーゼ － セレノシスティン － タンパク質フォールディング － 力場開発ヒトゲノムの解析によって、現在どの遺伝子がどのタンパク質になるのか―遺伝子...
Read moreMembers
Dr. Michio Iwaoka （Professor）Taku Shimosato (RA)Sayako Misawa(D1)Sawa Aka...
Read moreメンバー紹介
岩岡 道夫 （教授）下里 卓 （研究員）特定助手(D1)・1名三澤 颯子M2・2名赤星 佐和 ・池田 健人M1・1名嶋田 玲雄４年次生・6...
Read moreList of Publications
Year 2023Chalcogen-Containing Protein and Nucleic Acid Derivatives - Synthesis and A...
Read more論文リスト
２０２３年Chalcogen-Containing Protein and Nucleic Acid Derivatives - Synthesis and A...
Read more外国人訪問者
２０２３年Mr. Vishal Kaleeswaran (UM-DAE Centre for Excellence in Basic Sciences, India) 8/9/2...
Read moreVisitors
Year 2023Mr. Vishal Kaleeswaran (UM-DAE Centre for Excellence in Basic Sciences, India) 8...
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