Glutathione Peroxidase - Selenocysteine - Protein Folding - Force Field Development
After completion of the human genome project, people are now elaborating to mapping genes of all proteins. It used to be considered that the proteins are made of only 20 sorts of amino acids. However, a new amino acid has been discovered recently as the 21st proteinogenic amino acid. That is selenocysteine, a unique amino acid containing selenium and existing in various antioxidant enzymes. The target of our laboratory is to elucidate the molecular mechanisms of antioxidant functions of selenium and developing model reaction systems of selenoenzymes. We are also studying on "the principle that a three-dimensional protein structure voluntarily forms" and "the mechanism that the protein structure is stabilized by the interplay of atomic interactions" by using organic chemistry techniques, such as synthesis, calculation, and thermodynamic and kinetic analyses.
Enzyme Models of Glutathione Peroxidase (GPx)
Glutathione peroxidase is an antioxidant enzyme that contains a selenium atom at the acti...
Read moreSynthesis of Selenoamino Acids & Peptides
Cysteine and methionine are the amino acids with a sulfur atom, which can be a useful pro...
Read moreExperiments of Protein Folding
How does a protein fold ? When a protein folding experiment was carried out by ...
Read moreThe SAAP Force Field Project.
Even if we tried to observe protein folding processes by experiment, they cannot be seen ...
Read moreDatabase Analysis of Weak Interactions in Protein Architecture
Nonbonded interactions between a divalent sulfur atom and polar functional groups, i.e., ...
Read moreView of our laboratory
Experimental Group: Institute of Advanced Biosciences 3rd floorTheoretical Group: Institu...
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