List of Publications  Since2003


Year 2017

  1. Glutathione Peroxidase-Like Activity of Amino-Substituted Water-Soluble Cyclic Selenides: A Shift of the Major Catalytic Cycle in Methanol. Kenta Arai, Ayako Tashiro, Yuui Osaka, Michio Iwaoka, Molecules, 2017, 22, 354.
  2. Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue. Kenta Arai, Toshiki Takei, Masaki Okumura, Satoshi Watanabe, Yuta Amagai, Yuya Asahina, Luis Moroder, Hironobu Hojo, Kenji Inaba, Michio Iwaoka, Angew. Chem., Int. Ed., 2017, Apr 10. doi: 10.1002/anie.201701654.

Year 2016

  1. Alkyl Chain Modulated Cytotoxicity and Antioxidant Activity of Bioinspired Amphiphilic Selenolanes.
    Prachi Verma, Amit Kunwar, Kenta Arai, Michio Iwaoka, K. Indira Priyadarsini, Toxicol. Res., in press.
  2. Degradation of Peroxynitrite by Simple, Recyclable Selenolanes.
    Pavitra V. Kumar, Beena G. Singh, Amit Kunwar, Michio Iwaoka, K. Indira Priyadarsini, Bull. Chem Soc. Jpn., accepted.
  3. Tetrahydroselenophene. A Unique Structural Motif for Biological Applications.
    Kenta Arai, Michio Iwaoka, Curr. Org. Chem., 2016, 20, 155?165.
  4. Synthesis of Green Emission Upconversion Phosphor Nanosheets (LaNb2O7) Doped with Er3+ and Yb3+.
    Soichi Takasugi, Riku Iida, Koji Tomita, Michio Iwaoka, Kiyofumi Katagiri, Minoru Osada, Masato Kakihana, J. Luminescence, 2016, 173, 130?134.
  5. SAAP: A Program for Structure Prediction of Peptides. Toward Improvement of the Accuracy by Developing Three-Dimensional Main-Chain Parameters.
    Michio Iwaoka, Toshiki Suzuki, Natsuki Babe, Taku Shimosato, Toshiya Minezaki, Peptide Science 2015, 2016 99?100
  6. Screening of Er3+/Yb3+ Co-doped RE?Ta?O and RE?Nb?O (RE = Y, La, or Gd) Up-conversion Phosphors. Sayaka Tamura, Michio Iwaoka, Yasushi Sato, Makoto Kpbayashi, Masato Kakihana, Koji Tomita, Chem. Lett., 2016, 45, 890?891.
  7. Dihydroxyselenolane (DHS) Supplementation Improves Survival Following Whole-Body Irradiation (WBI) by Suppressing Tissue-Specific Inflammatory Responses. Amit Kunwar, Prachi Verma, H. N. Bhilwade, Michio Iwaoka, K. Indira Priyadarsini, Mutat. Res. ? Gen. Toxicol. Environ. Mutagen., 2016, 807, 33?46.
  8. Gold nanoparticle induced redox modulation in organoselenium compounds: Distinction between cyclic vs. linear structures. Pavitra V. Kumar, Beena G. Singh, Anand Balla, Vimal K. Jain, Michio Iwaoka, K. Indira Priyadarsini, RSC Advances, 2016, 6, 69501?69508.
  9. Synthesis of L-Selenocysteine and α-Methyl-L-Selenocysteine Derivatives Using Woollins' Reagent and Their Application as Chiral Selenium Catalysts. Michio Iwaoka, Shun Ito, Izumo Miyazaki, Momoko Michibata, Proc. Natl. Acad. Sci., India, Sect. A Phys. Sci., 2016, 86, 499?509.
  10. Improved Synthetic Routes to the Selenocysteine Derivatives Useful for Boc-Based Peptide Synthesis with Benzylic Protection on the Selenium Atom. Shingo Shimodaira, Michio Iwaoka, Arch. Org. Chem (ARKIVOC), 2016, 2017(2), 260?271.

Year 2015

  1. Synthesis, Characterization, and Structure of trans-3,4-dihydroxy-1-selenolane {DHS(OH)2} Substituted Derivatives.
    Prasad P. Phadnis, Amey Wadawale, K. I. Priyadarsini, Vimal K. Jain, Michio Iwaoka, Tetrahedron Lett., 2015, 56, 2293-2296.
  2. The Hydrothermal and Solvothermal Synthesis of LiTaO3 Photocatalyst: Suppressing the Deterioration of the Water Splitting Activity Without Using a Cocatalyst.
    Soichi Takasugi, Koji Tomita, Michio Iwaoka, Hideki Kato, Masato Kakihana, Int. J. Hydrogen Energy, 2015, 40, 5638-5643.
  3. Fatty Acid Conjugates of Water-Soluble (±)-trans- Selenolane-3,4-diol: Effects of Alkyl Chain Length on the Antioxidant Capacity.
    Michio Iwaoka, Nobukazu Sano, Ying-Yin Lin, Arisa Katakura, Masato Noguchi, Kohei Takahashi, Fumio Kumakura, Kenta Arai, Beena G. Singh, Amit Kunwar, K. Indira Priyadarsini, ChemBioChem, 2015, 16(8), 1226-1234.
  4. Effects of Ring Size and Polar Functional Groups on the Glutathione Peroxidase-Like Antioxidant Activity of Water-Soluble Cyclic Selenides.
    Kenta Arai, Fumio Kumakura, Motoi Takahira, Natsumi Sekiyama, Nozomi Kuroda, Toshiki Suzuki, Michio Iwaoka, J. Org. Chem., 2015, 80, 5633-5642.
  5. Mimicking the Lipid Peroxidation Inhibitory Activity of Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) by Using Fatty Acid Conjugates of a Water-soluble Selenolane.
    Michio Iwaoka, Arisa Katakura, Jun Mishma, Yoshimi Ishihara, Amit Kunwar, K. Indira Priyadarsini, Molecules, 2015, 20, 12364-12375.
  6. Mining and Structural Characterization of S・・・X Chalcogen Bonds in Protein Database.
    Michio Iwaoka, Natsuki Babe, Phosph. Sulf. Silic. and The Related Elements, 2015, 190, 1257?1264. [DOI:10.1080/10426507.2014.1002612].
  7. Chalcogen Bonds in Protein Architecture.
    Michio Iwaoka, in Noncovalent Forces, edited by S. Scheiner, Challenges and Advances in Computational Chemistry and Physics 19, Springer, 2015, Chapter 9, 265-289.

Year 2014

  1. Model Study Using Designed Selenopeptides on the Importance of the Catalytic Triad for the Antioxidative Functions of Glutathione Peroxidase.
    Toshiki Takei, Yoshiko Urabe, Yuya Asahina, Hironobu Hojo, Takeshi Nomura, Kenichi Dedachi, Kenta Arai, Michio Iwaoka, J. Phys. Chem. B, 2014, 118, 492-500.
  2. Stable Selones in Glutathione Peroxidase Like Catalytic Cycle of Selenonicotinamide Derivative.
    Parashiva Prabhu, Beena G. Singh, Masato Noguchi, Prasad P. Phadnis, Vimal K. Jain, Michio Iwaoka, K. Indira Priyadarsini, Org. Biomol. Chem., 2014, 12, 2404-2412.
  3. Antioxidant Organoselenium Molecules.
    Michio Iwaoka, in Organoselenium Chemistry Between Synthesis and Biochemistry, edited by C. Santi and C. Tidei, Bentham Science Publishers, 2014, Chapter 12, 361-378.
  4. DL-trans-3,4-Dihydroxy-1-Selenolane (DHSred) Heals Indomethacin-Mediated Gastric Ulcer in Mice by Modulating Arginine Metabolism.
    Saikat Chakraborty, Sudhir Yadav, Mahesh Subramanian, Michio Iwaoka, Subrata Chattopadhyay, Biochim. Biophys. Acta, 2014, 1840, 3385-3392.
  5. Binding of a Cyclic Organoselenium Compound with Gold Nanoparticles (GNP) and its Effect on Electron Transfer Properties.
    Pavitra V. Kumar, Beena G. Singh, Nandita Maiti, Michio Iwaoka, K. Indira Priyadarsini, J. Coll. Interface Sci., 2014, 436, 179-185.
  6. An Amphiphilic Selenide Catalyst Behaves Like a Hybrid Mimic of Protein Disulfide Isomerase (PDI) and Glutathione Peroxidase 7 (GPx7).
    Kenta Arai, Kenji Moriai, Akinobu Ogawa, Michio Iwaoka, Chem.- An Asian J., 2014, 9, 3464-3471. (Back cover picture)

Year 2013

  1. A Water-Soluble Selenoxide Reagent as a Useful Probe for the Reactivity and Folding of Polythiol Peptides.
    Kenta Arai, Masato Noguchi, Beena G. Singh, K. Indira Priyadarsini, Katsuhiko Fujio, Yurika Kubo, Kyoko Takayama, Setsuko Ando, Michio Iwaoka, FEBS Open Bio, 2013, 3, 55?64.
  2. From Sulfur to Selenium. A New Research Arena in Chemical Biology and Biological Chemistry.
    Michio Iwaoka, Kenta Arai, Curr. Chem. Biol., 2013, in print.
  3. Toward Structure Prediction for Short Peptides Using the Improved SAAP Force Field Parameters.
    Kenichi Dedachi, Taku Shimosato, Toshiya Minezaki, Michio Iwaoka, J. Chem., 2013, Article ID 407862, 13 pages.
  4. Reinvestigation of the Oxidative Folding Pathways of Hen Egg White Lysozyme: Switching of the Major Pathways by Temperature Control.
    Kenta Arai, Wataru Shibagaki, Reina Shinozaki, Michio Iwaoka, Int. J. Mol. Sci., 2013, 14, 13194-13212.
  5. Synthesis and Morphology Control of YBO3:Tb3+ Green Phosphor by Precipitation from Homogeneous Solution.
    Noriyuki Naruse, Koji Tomita, Michio Iwaoka, Masato Kakihana, J. Ceram. Soc. Jpn., 2013, 121, 502?505.
  6. Radical Cations of Aromatic Selenium Compounds: Role of Se???X Non-Bonding Interactions.
    Beena G. Singh, Elizabeth Thomas, Shilpa Sawant, Kohei Takahashi, Kenichi Dedachi, Michio Iwaoka, K. Indira Priyadarsini, J. Phys. Chem. A, 2013, 117, 9259-9265.
  7. Emulating Antioxidative Functions of Glutathione Peroxidase Using Selenopeptides.
    Michio Iwaoka, in Biochalcogen Chemistry: The Biological Chemistry of Sulfur, Selenium, and Tellurium, edited by Craig A. Bayse and Julia L. Brumaghim, ACS Symposium Series, American Chemical Society, 2013, 1152, 163?177.

Year 2012

  1. Nucleophilic Selenium.
    Michio Iwaoka, in Organoselenium Chemistry: Synthesis and Reactions, edited by T. Wirth, Wiley-VCH Verlag GmbH & Co. KGaA, 2012, 53?109.
  2. Kinetic and Thermodynamic Analysis of the Conformational Folding Process of SS-Reduced Bovine Pancreatic Ribonuclease A Using a Selenoxide Reagent with High Oxidizing Ability.
    Kenta Arai, Fumio Kumakura, Michio Iwaoka, FEBS Open Bio, 2012, 2, 60-70. (DOI: 10.1016/j.fob.2012.04.001)
  3. Hypervalent Nonbonded Interactions of a Divalent Sulfur Atom. Implications in Protein Architecture and the Functions.
    Michio Iwaoka, Noriyoshi Isozumi, Molecules, 2012, 17, 7266?7283.
  4. DL-trans-3,4-Dihydroxy-1-Selenolane (DHSred) Accelerates Healing of Indomethacin-Induced Stomach Ulceration in Mice.
    Saikat Chakraborty, Sudhir Yadav, Magesh Subramanian, K. I. Priyadarsini, Michio Iwaoka, Subrata Chattopadhyay, Free Radical Res., 2012, 46, 1378?1386.

Year 2011

  1. Effect of Functional Groups on Antioxidant Properties of Substituted Selenoethers.
    P. Prabhu, P. P. Bag, B. G. Singh, A. Hodage, V. K. Jain, M. Iwaoka, and K. I. Priyadarsini, Free Radical Res., 2011, 45, 461?468.
  2. Antioxidative Glutathione Peroxidase Activity of Selenoglutathione.
    Sari Yoshida, Fumio Kumakura, Itsuki Komatsu, Kenta Arai, Yuko Onuma, Hironobu Hojo, Beena G. Singh, K. Indira Priyadarsini, Michio Iwaoka, Angew. Chem. Int. Ed., 2011, 50, 2125?2128.
  3. Rapid and Quantitative Disulfide Bond Formation for a Polypeptide Chain Using a Cyclic Selenoxide Reagent in an Aqueous Medium.
    Kenta Arai, Kenichi Dedachi, Michio Iwaoka, Chem. Eur. J., 2011, 17, 481?485. (selected as VIP and Cover picture)
  4. One-Pot Conversion of Serine and alpha-Methylserine Derivatives to the Corresponding Cysteines and Selenocystines by Using Chalcogenophosphate Reagents.
    Akira Makiyama, Itsuki Komatsu, Michio Iwaoka, Masanobu Yatagai, Phosph. Sulf. Silic. and The Related Elements, 2011, 186, 125-133.

Year 2010

  1. Characterization of Kinetic and Thermodynamic Phases in the Pre-Folding Process of Bovine Pancreatic Ribonuclease A Coupled with Fast SS Formation and SS Reshuffling.
    Kenta Arai, Fumio Kumakura, Michio Iwaoka, Biochemistry, 2010, 49, 10535?10542.
  2. One-Electron Redox Processes in a Cyclic Selenide and a Selenoxide: A Pulse Radiolysis Study.
    Beena G. Singh, Elizabeth Thomas, Fumio Kumakura, Kenichi Dedachi, Michio Iwaoka, K. Indira Priyadarsini, J. Phys. Chem. A, 2010, 114, 8271?8277.
  3. Structural Transitions and an Enzymatic Function of Ribonuclease A Encapsulated in Transparent Porous Silica Gel.
    Michio Iwaoka, Nobukazu Sano, Norikazu Hasegawa, Mariko Yokokawa, Satoko Kunigami, Hiroyuki Shirai, Bull. Chem. Soc. Jpn., 2010, 83, 935-941.
  4. Novel Cyclization Cascades to Functionalized Indanes and Tetrahydronaphthalenes.
    Zulfiqar A. Khan, Michio Iwaoka, Thomas Wirth, Tetrahedron, 2010, 66, 6639-6646.
  5. Synthesis of New Sulfoxide Containing Diselenides and Unexpected Cyclization Reactions to (2,3-Dihydro-1,4-benzoselenothiine-1-oxides).
    Diana M. Freudendahl, Michio Iwaoka, Thomas Wirth, Eur. J. Org. Chem., 2010, 3934-3944.
  6. Role of Substrate Reactivity in the Glutathione Peroxidase (GPx) Activity of Selenocystine.
    Beena Singh, Partha P. Bag, Fumio Kumakura, Michio Iwaoka, K. Indira Priyadarsini, Bull. Chem. Soc. Jpn., 2010, 83, 703-708.
  7. A Water-Soluble Cyclic Selenide with Enhanced Glutathione Peroxidase-Like Catalytic Activities.
    Fumio Kumakura, Beena Mishra, K. Indira Priyadarsini, Michio Iwaoka, Eur. J. Org. Chem., 2010, 440-445.

Year 2009

  1. The SAAP Force Field. Development of the Single Amino Acid Potentials for Twenty Proteinogenic Amino Acids and Monte Carlo Molecular Simulation for Short Peptides.
    Michio Iwaoka, Naoki Kimura, Daisuke Yosida, Toshiya Minezaki, J. Comput. Chem., 2009, 30, 2039-2055.

Year 2008

  1. Direct Observation of Conformational Folding Coupled with Disulphide Rearrangement by Using a Water-Soluble Selenoxide Reagent. A Case of Oxidative Regeneration of Ribonuclease A under Weakly Basic Conditions.
    Michio Iwaoka, Fumio Kumakura, Mitsumasa Yoneda, Toshitaka Nakahara, Kayo Henmi, Hiromi Aomuna, Hiroyasu Nakatani, Shuji Tomoda, J. Biochem., 2008, 144, 121-130.
  2. Synthesis of Selenocysteine and Selenomethionine Derivatives from Sulfur-Containing Amino Acids.
    Michio Iwaoka, Ryuta Ooka, Toshifumi Nakazato, Sari Yoshida, Sadahiro Oishi, Chem. Biodiv., 2008, 5, 359-374.
  3. Applications of Water-Soluble Selenides and Selenoxides to Protein Chemistry.
    Michio Iwaoka, Fumio Kumakura, Phosph. Sulf. Silic. and The Related Elements, 2008, 183, 1009-1017.
  4. Stereoselective Synthesis of Benzyl-Protected ?-Galactosides by Propionitrile-Mediated Glycosylation.
    Akiharu Ueki, Masafumi Hirota, Yuta Kobayashi, Keiko Komatsu, Yutaka Takano, Michio Iwaoka, Yuko Nakahara, Hironobu Hojo, Yoshiaki Nakahara, Tetrahedron, 2008, 64, 2611-2618.

Year 2006

  1. Importance of the Single Amino Acid Potential (SAAP) in Water for Secondary and Tertiary Structures of Proteins.
    Michio Iwaoka, Daisuke Yosida, Naoki Kimura, J. Phys. Chem. B, 2006, 110, 14475-14482.
  2. Synthesis of Selenocystine Derivatives from Cystine by Applying the Transformation Reaction from Disulfides to Diselenides.
    Michio Iwaoka, Chie Haraki, Ryuta Ooka, Masahiro Miyamoto, Ai Sugiyama, Yumiko Kohara, Noriyoshi Isozumi, Tetrahedron Lett., 2006, 47, 3861-3863.
  3. Possible Roles of S•••O and S•••N Interactions in the Functions and Evolution of Phospholipase A2.
    Michio Iwaoka, Noriyoshi Isozumi, BIOPHYSICS, 2006, 2, 23-34.
  4. Molecular Simulation of Polypeptides in Water Based on the Single Amino Acid Potential (SAAP) Force Field.
    Michio Iwaoka, Naoki Kimura, Toshiya Minezaki, Peptide Science, 2006, 137.

Year 2005

  1. Experimental and Theoretical Studies on the Nature of Weak Nonbonded Interactions between Divalent Selenium and Halogen Atoms.
    Michio Iwaoka, Takayuki Katsuda, Hiroto Komatsu, Shuji Tomoda, J. Org. Chem., 2005, 70, 321-327.
  2. Physical- and Bio-organic Chemistry of Nonbonded Selenium•••Oxygen Interactions.
    Michio Iwaoka, Shuji Tomoda, Phosph. Sulf. Silic. and The Related Elements, 2005, 180, 755-766.
  3. Studies on the Nonbonded Interactions of Divalent Organic Selenium.
    Michio Iwaoka and Shuji Tomoda, J. Synth. Org. Chem., 2005, 63(9), 911-920.
  4. NBO Analysis. Michio Iwaoka, J. Synth. Org. Chem., 2005, 63(9), 921.

Year 2004

  1. The SAAP Force Field. Development of a New Protein Force Field by Using a Single Amino Acid Potentials.
    Michio Iwaoka, Seibutsu-Butsuri, 2004, 44(2), 64-69.
  2. Nature of Nonbonded Se•••O Interactions Characterized by 17O NMR Spectroscopy and NBO and AIM Analyses.
    Michio Iwaoka, Hiroto Komatasu, Takayuki Katsuda, Shuji Tomoda, J. Am. Chem. Soc., 2004, 126, 5309-5317.

Year 2003

  1. Statistical and Theoretical Study on the Directionality of Nonbonded S•••O Interactions. Implications for Molecular Design and Protein Engineering. Michio Iwaoka, Genome News, 2003, No. 5, 29-31.
  2. The SAAP Force Field. A Simple Approach to a New All-Atom Protein Force Field by Using Single Amino Acid Potential (SAAP) Functions in Various Solvents.
    Michio Iwaoka, Shuji Tomoda, J. Comput. Chem., 2003, 24, 1192-1200.